KCNQ1 Antibody: ATTO 488

KCNQ1 Antibody: ATTO 488

• Background: Kv7.1 (KvLQT1) is a potassium channel protein coded for by the gene KCNQ1. Kv7.1 is present in the cell membranes of cardiac muscle tissue and in inner ear neurons (1) among other tissues. In the cardiac cells, Kv7.1 mediates the IKs (or slow delayed rectifying K+) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction (2, 3).
• Description: Mouse Anti-Human KCNQ1 Monoclonal IgG1
• Specifications: Detects ~75kDa.
• Alternative Name: ATFB1 Antibody, ATFB3 Antibody, FLJ26167 Antibody, IKs producing slow voltage-gated potassium channel subunit alpha Antibody, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 Antibody, Jervell and Lange-Nielsen syndrome 1 Antibody, JLNS1 Antibody, KCNA8 Antibody, KCNA9 Antibody, KCNQ1 Antibody, KCNQ1_HUMAN Antibody, kidney and cardiac voltage dependend K+ channel Antibody, KQT-like 1 Antibody, Kv1.9 Antibody, Kv7.1 Antibody, KVLQT1 Antibody, long (electrocardiographic) QT syndrome Antibody, Ward-Romano syndrome 1 Antibody, LQT Antibody, LQT1 Antibody, Potassium voltage-gated channel subfamily KQT member 1 Antibody, potassium voltage-gated channel KQT-like subfamily member 1 Antibody, RWS Antibody, slow delayed rectifier channel subunit Antibody, SQT2 Antibody, Voltage-gated potassium channel subunit Kv7.1 Antibody, WRS Antibody
• Synonyms: KCNQ1 Antibody, Clone N37A/10: ATTO 488
• UNSPSC: 12352203
• Gene ID: 3784
• Swiss Prot: P51787
• Accession Number: NP_000209.2
• Cellular Locus: Cell Membrane | Cytoplasmic Vesicle Membrane
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat, Hamster
• Immunogen: Fusion protein amino acids 2-101 of human KCNQ1
• Target: KCNQ1
• Clonality: Monoclonal
• Isotype: IgG1
• Clone: N37A/10 (Formerly sold as S37A-10)
• Conjugation: ATTO 488
• Validated Applications: IHC, ICC/IF
• Purification: Protein G Purified
• Limit Of Detection: 1 µg/ml of SMC-307 was sufficient for detection of KCNQ1 in 10 µg of COS-1 cell lysate transiently expressing KCNQ1 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
• Concentration: 1 mg/ml
• Dilution: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
• Weight: 0.1
• Buffer: 640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS
• Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• References & Citations: 1. Lang F., Vallon V., Knipper M., Wagenmann P. (2007) Am J Physiol. 293(4): C1187-1208. 2. Kurokawa J., et al. (2009) Channels (Austin). 3(1): 16-24. 3. Silva J., and Rudy Y. (2005) Circulation. 112(10): 1384-1391.