LAMP2 Antibody, Clone GL2A7

CAT: 0400-SMC-141SSize: 12 µgDry Ice: NoHazardous: No
CAT#:0400-SMC-141SSize:12 µg
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Background
LAMP2 (Lysosome-Associated Membrane Protein 2) is a transmembrane glycoprotein essential for lysosomal function and autophagy. It facilitates the maturation of autophagic vacuoles and the degradation of cellular debris. LAMP2 is expressed in lysosomes, late endosomes, and at the plasma membrane, where it may mediate cell-cell and cell-matrix interactions. In neurodegenerative diseases, LAMP2 deficiency or dysfunction impairs autophagic clearance, leading to the accumulation of toxic proteins and organelles. This contributes to neuronal death in disorders such as Danon disease, Parkinson’s disease, and Alzheimer’s disease. LAMP2 also participates in immune responses, promoting leukocyte adhesion and mast cell activation. Its role in lysosomal trafficking and neuroinflammation underscores its importance as a biomarker and therapeutic target in neurodegeneration.
Description
Rat Anti-Mouse LAMP2 Monoclonal IgG1
CAS Number
9007-83-4
Specifications
Detects ~100-110kDa.
Product Name Alternative
LAMP2, LAMP-2, Lamp2C, Lysosome-associated membrane glycoprotein 2, Lysosome-associated membrane protein 2, CD107b, CD107 antigen-like family member B, Lysosomal membrane glycoprotein type B, LGP-B, Igp110, Igp2, LampB, MAC3
Synonyms
LAMP2 Antibody, Clone GL2A7
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
16784
Swiss Prot
P17047
Accession Number
NP_001017959.1
Cellular Locus
Cell Membrane | Endosome | Lysosome | Endosome membrane | Lysosome membrane
Host
Rat
Species Reactivity
Human, Mouse, Rabbit
Immunogen
Purified preparation of mouse liver lysosomal membranes
Target
LAMP2
Clonality
Monoclonal
Isotype
IgG1
Clone
GL2A7
Conjugation
Unconjugated
Type
Monoclonal
Applications
WB | ICC/IF | IP
Validated Applications
WB, ICC/IF, IP
Field of Research
Cell Signaling | Tags and Cell Markers | Organelle Markers | Protein Trafficking | Chaperone Proteins | Neuroscience
Purification
Protein G Purified
Limit Of Detection
1 µg/ml of SMC-141 was sufficient for detection of LAMP2 in 20 µg of rat liver microsomes by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:500) ; optimal dilutions for assays should be determined by the user.
Weight
0.012
Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Granger B.L., et al. (1990) J. Biol. Chem. 265: 12036-12043. 2. Furuta K., et al. (1999) EMBO J. 17(5):1304-14. 3. Rohrer J., et al. (1996) J Cell Biol. 132(4): 565-76. 4. Lichter-Konecki U., et al (1999) Differentiation 65(1): 43-58. 5. Grutzkau A., et al. (2004) Cytometry A. 61(1): 62-68. 6. Kannan K., et al. (1996) Cell Immunol. 171: 10-19. 7. Tanaka Y., et al. (2000) Nature 406: 902-906.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~100-110kDa.
Background Reference 01
1. Granger B.L., et al. (1990) J. Biol. Chem. 265: 12036-12043. 2. Furuta K., et al. (1999) EMBO J. 17 (5) :1304-14. 3. Rohrer J., et al. (1996) J Cell Biol. 132 (4) : 565-76. 4. Lichter-Konecki U., et al (1999) Differentiation 65 (1) : 43-58. 5. Grutzkau A., et al. (2004) Cytometry A. 61 (1) : 62-68. 6. Kannan K., et al. (1996) Cell Immunol. 171: 10-19. 7. Tanaka Y., et al. (2000) Nature 406: 902-906.
Species
Human | Mouse | Rabbit
Location
Cell Membrane | Endosome | Lysosome | Endosome membrane | Lysosome membrane
Isotype
IgG1
Immunogen Species
Mouse

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