Fenoterol

• Description :

  Fenoterol (Th-1165), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research[1][2].

• CAS Number :

  [13392-18-2]

• Product Name Alternative :

  Th-1165; Phenoterol

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H332

• Target :

  Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Inflammation/Immunology; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/Fenoterol.html

• Concentration :

  10mM

• Purity :

  99.08

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC1=CC(C(O)CNC(C)CC2=CC=C(O)C=C2)=CC(O)=C1

• Molecular Formula :

  C17H21NO4

• Molecular Weight :

  303.35

• Precautions :

  H302, H312, H332

• References & Citations :

  [1]Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8 (1) :8161.|[2]R C Heel, et al. Fenoterol: a review of its pharmacological properties and therapeutic efficacy in asthma. Drugs. 1978 Jan;15 (1) :3-32.|[3]Wei Wang, et al. Anti-inflammatory activities of fenoterol through β-arrestin-2 and inhibition of AMPK and NF-κB activation in AICAR-induced THP-1 cells. Biomed Pharmacother. 2016 Dec;84:185-190.|[4]Nada Choucair-Jaafar, et al. Beta2-adrenoceptor agonists alleviate neuropathic allodynia in mice after chronic treatment. Br J Pharmacol. 2009 Dec;158 (7) :1683-94.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  β adrenergic receptor