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TTK21

CAT: 0804-HY-116673-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116673-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 passes the blood–brain barrier, induces no toxicity, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP) . TTK21 has beneficial implications for the brain functions of neurogenesis and long-term memory[1].CSP-TTK21 can ameliorate Aβ-impaired long-term potentiation (LTP) . CSP-TTK21 may enhance the transcription of genes that promote synaptic health and cognitive function[2]. CSP-TTK21 is orally effective and leads to improvements in motor functions, histone acetylation dynamics in a spinal injury rat model[3].
CAS Number
709676-56-2
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ttk21.html
Purity
99.39
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC1=CC=C(C=C1C(F)(F)F)NC(C2=CC=CC=C2OCCC)=O
Molecular Formula
C17H15ClF3NO2
Molecular Weight
357.75
Precautions
H315, H319
References & Citations
[1]Chatterjee S, et al. A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice. J Neurosci. 2013;33 (26) :10698-10712.|[2]Singh A et al. Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid-beta 1-42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons. Aging Cell. 2022 Sep;21 (9) :e13675.|[3]Singh A, et al. Oral administration of a specific p300/CBP Lysine acetyltransferase activator induces synaptic plasticity and repairing spinal cord injury[J]. bioRxiv, 2023: 2023.10. 04.560982.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300

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