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Swertiamarin (Standard)

CAT: 0804-HY-N0807RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N0807RSize:1 Each
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Description
Swertiamarin (Standard) is the analytical standard of Swertiamarin. This product is intended for research and analytical applications. Swertiamarin is an orally active iridoid compound with hypoglycemic, hypolipidemic, anti rheumatic and antioxidant activities, which can be used in the research of diabetes and arthritis[1][2][4][5].
CAS Number
17388-39-5
UNSPSC
12352005
Target
JAK; Keap1-Nrf2; MMP; NF-κB; Reference Standards
Type
Reference Standards
Related Pathways
Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/swertiamarin-standard.html
Smiles
C=C[C@@H]([C@@H]1O[C@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CO)[C@@](C3=CO1)(CCOC3=O)O
Molecular Formula
C16H22O10
Molecular Weight
374.34
References & Citations
[1]Vaidya H, et al. Swertiamarin: a lead from Enicostemma littorale Blume. for anti-hyperlipidaemic effect. Eur J Pharmacol. 2009 Sep 1;617 (1-3) :108-12. |[2]Wu T, et al. Antioxidant and Hepatoprotective Effect of Swertiamarin on Carbon Tetrachloride-Induced Hepatotoxicity via the Nrf2/HO-1 Pathway. Cell Physiol Biochem. 2017;41 (6) :2242-2254.|[3]Hairul-Islam MI, et al. Swertiamarin, a natural steroid, prevent bone erosion by modulating RANKL/RANK/OPG signaling. Int Immunopharmacol. 2017 Dec;53:114-124. |[4]Saravanan S, et al. Swertiamarin attenuates inflammation mediators via modulating NF-κB/I κB and JAK2/STAT3 transcription factors in adjuvant induced arthritis. Eur J Pharm Sci. 2014 Jun 2;56:70-86.|[5]Vaidya H, et al. Anti-diabetic activity of swertiamarin is due to an active metabolite, gentianine, that upregulates PPAR-γ gene expression in 3T3-L1 cells. Phytother Res. 2013 Apr;27 (4) :624-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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