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COH34

CAT: 0804-HY-128760-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128760-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COH34 is a potent and specific poly (ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].
CAS Number
906439-72-3
UNSPSC
12352005
Target
Poly (ADP-ribose) Glycohydrolase (PARG)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/coh34.html
Purity
99.92
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
CC1=CC=C(S/N=C/C2=C3C=CC=CC3=CC=C2O)C=C1
Molecular Formula
C18H15NOS
Molecular Weight
293.38
References & Citations
[1]Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5 (4) :eaav4340.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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