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Declopramide

CAT: 0804-HY-111193-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111193-01Size:1 mg
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Description
Declopramide (3-Chloroprocainamide) is an orally active antitumor agent, which inhibits proliferation of cancer cells HL60 and K562, and inhibits tumor growth of human brain astrocytoma (T24) in mouse model. Declopramide induces apoptosis, inhibits NF-κB through inhibition of IκBα degradation. Declopramide serves also as chemosensitizer in research[1][2][3].
CAS Number
891-60-1
Product Name Alternative
3-Chloroprocainamide
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; NF-κB
Type
Reference compound
Related Pathways
Apoptosis; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/declopramide.html
Smiles
O=C(NCCN(CC)CC)C1=CC=C(N)C(Cl)=C1
Molecular Formula
C13H20ClN3O
Molecular Weight
269.77
Precautions
P264-P270-P330-P501
References & Citations
[1]Hua J, et al., Comparison of antitumor activity of declopramide (3-chloroprocainamide) and N-acetyl-declopramide. Anticancer Res. 1999 Jan-Feb;19 (1A) :285-90. |[2]Hua J, et al., Pharmacokinetics and central nervous system toxicity of declopramide (3-chloroprocainamide) in rats and mice. Anticancer Drugs. 1999 Jan;10 (1) :79-88. |[3]Lindgren H, et al., Differential usage of IkappaBalpha and IkappaBbeta in regulation of apoptosis versus gene expression. Biochem Biophys Res Commun. 2003 Jan 31;301 (1) :204-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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CatalogName
T27138-01Declopramide

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