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Clebopride

CAT: 0804-HY-B1613Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B1613Size:1 Each
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Description
Clebopride is an orally active dopamine Receptor antagonist. Clebopride acts on dopamine D2 receptors and has antiemetic and prokinetic effects. Clebopride can be used in the study of functional gastrointestinal disorders[1][2][3][4].
CAS Number
[55905-53-8]
UNSPSC
12352005
Hazard Statement
H302
Target
Adrenergic Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/clebopride.html
Smiles
O=C(NC1CCN(CC2=CC=CC=C2)CC1)C3=CC(Cl)=C(N)C=C3OC
Molecular Formula
C20H24ClN3O2
Molecular Weight
373.88
Precautions
P264-P270-P330-P501
References & Citations
[1]Reis-Carneiro D, et al. Clebopride-Associated Movement Disorders. Mov Disord Clin Pract. 2023 Sep 6;10 (10) :1562-1563.|[2]Elliott PN, et al. Substituted benzamides as cerebral dopamine antagonists in rodents. Neuropharmacology. 1977 May;16 (5) :333-42.|[3]Segura J, et al. The pharmacokinetics of a new benzamide drug clebopride, in the rat and the dog. J Pharm Pharmacol. 1981 Apr;33 (4) :214-8.|[4]Takeda K, et al. Clebopride enhances contractility of the guinea pig stomach by blocking peripheral D2 dopamine receptor and alpha-2 adrenoceptor. J Pharmacol Exp Ther. 1991 May;257 (2) :806-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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270463-01Clebopride Maleate Salt
RM-C121003-01Clebopride Malate EP Impurity C
RM-C121002-01Clebopride Malate EP Impurity B
RM-M200303-01Metoclopramide EP Impurity C; Clebopride Malate EP Impurity A
RM-C121001-01Clebopride Malate EP Impurity A discontinued see RM-M200303

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