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(-) BI97D6

CAT: 0804-HY-115529Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-115529Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(-) BI97D6 is a broad-spectrum inhibitor of the Bcl-2 protein family, inhibiting Mcl-1, Bcl-2, Bcl-xL and Bcl-1 with IC50 values ​​of 0.025, 0.031, 0.076 and 0.122 μM, respectively. (-) BI97D6 stimulates cell death through the Bak and Bax mediated mitochondrial apoptosis pathway. In addition, (-) BI97D6 inhibits Mcl-1 and can effectively induce apoptosis in acute myeloid leukemia (AML) cells[1].
CAS Number
1430067-36-9
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/minus-bi97d6.html
Smiles
O=C1C2=CC(O)=C(C(CC3=CC=CC=C3)=C2C(C(C)=C1C(C(C4=CC(O)=C(C(CC5=CC=CC=C5)=C46)O)=O)=C(C)C6=O)=O)O
Molecular Formula
C36H26O8
Molecular Weight
586.59
References & Citations
[1]Rongqing Pan, et al. "Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–) BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia." Blood, The Journal of the American Society of Hematology 126.3 (2015) : 363-372.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-xL; Mcl-1

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CatalogName
M11053(-) BI97D6

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