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ARM165

CAT: 0804-HY-163677-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-163677-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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UNSPSC Description
ARM165 is a heterobifunctional molecule. ARM165 degrades the PIK3CG proteins, inhibits PI3Kγ-Akt signaling pathway, and thus exhibits antileukemia efficacy. ARM165 inhibits proliferations of AML cells, with IC50 [1]
Target Antigen
Akt; PI3K; PROTACs
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR;PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/arm165.html
Solubility
DMSO : 28.57 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CC1=C2C(N(CC2=CC(C3=C(N=C(S3)NC(CCCC(NCCCCCCCC(NC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O)=O)=O)=O)C)=C1)[C@H](C7CC7)C)=O
Molecular Weight
837.98
References & Citations
[1]Kelly LM, et al., Targeting a lineage-specific PI3Kɣ-Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule. Nat Cancer. 2024 May 30.
Shipping Conditions
Blue Ice
Clinical Information
No Development Reported

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