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SN05

CAT: 0804-HY-146242-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-146242-07Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SN05 is a potent amino acid transport (AAT) inhibitor with Ki values of 2.77 μM, 0.73 μM, 0.87 μM, 3.7 μM, 7.25 μM, 7.23 μM and 2.22 μM for hASCT1, rASCT2, hASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN05 can be used in the study of cancer[1].
CAS Number
2768663-51-8
UNSPSC
12352005
Target
ASCT; EAAT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sn05.html
Concentration
10mM
Purity
98.37
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC([C@@H](NC1)C[C@@H]1OC(C2=CC=C(C3=CC=CC=C3)C=C2)=O)=O
Molecular Formula
C18H17NO4
Molecular Weight
311.33
References & Citations
[1]Christof GREWER, et al. Inhibitors of amino acid transport. WO2022087630A1. 2022-04-28.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ASCT2; EAAT1; EAAT2; EAAT3; EAAT5

Chemical Information

(2~{S},4~{S})-4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid
CAS Number2768663-51-8
PubChem CID156599525
IUPAC Name(2S,4S)-4-(4-phenylbenzoyl)oxypyrrolidine-2-carboxylic acid
Molecular FormulaC18H17NO4
Molecular Weight311.3
XLogP0.5
Topological Polar Surface Area75.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count23
Formal Charge0
Complexity425
SMILES
C1[C@@H](CN[C@@H]1C(=O)O)OC(=O)C2=CC=C(C=C2)C3=CC=CC=C3
InChI
InChI=1S/C18H17NO4/c20-17(21)16-10-15(11-19-16)23-18(22)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15-16,19H,10-11H2,(H,20,21)/t15-,16-/m0/s1
InChIKey
GCIZCIZLSHSWDS-HOTGVXAUSA-N
Chemical Structure
2D Structure
2D structure of (2~{S},4~{S})-4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid
CAS: 2768663-51-8
CID: 156599525
Formula: C18H17NO4
MW: 311.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight311.3
XLogP30.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass311.11575802
Monoisotopic Mass311.11575802
Topological Polar Surface Area75.6 Ų
Heavy Atom Count23
Formal Charge0
Complexity425
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19187696-01SN05

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