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Pramipexole (Standard)

CAT: 0804-HY-B0410R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0410R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pramipexole (Standard) is the analytical standard of Pramipexole. This product is intended for research and analytical applications. Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS) [1][2][3].
CAS Number
104632-26-0
UNSPSC
12352005
Target
Dopamine Receptor; Reference Standards
Type
Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pramipexole-standard.html
Smiles
NC1=NC(CC[C@H](NCCC)C2)=C2S1
Molecular Formula
C10H17N3S
Molecular Weight
211.33
References & Citations
[1]Kvernmo, T., et al. A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin Ther, 2006. 28 (8) : p. 1065-78.|[2]Takashi Okura, et al. Blood-brain barrier transport of pramipexole, a dopamine D2 agonist. Life Sci. 2007 Apr 3;80 (17) :1564-71.|[3]Ginetta Collo, et al. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 2018; 2018: 4196961.|[4]P M Carvey, et al. Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole. J Neural Transm (Vienna) . 1997;104 (2-3) :209-28.|[5]Syed Suhail Andrabi, et al. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Dis Model Mech. 2019 Aug 1; 12 (8) : dmm033860.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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