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VRK1 Polyclonal Antibody

CAT: 0749-ABP60902-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP60902-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. VRK1 is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. VRK1, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
Description
Rabbit Anti-VRK1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Serine/threonine-protein kinase VRK1; Vaccinia-related kinase 1
Gene ID
7443
Accession Number
Q99986
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human VRK1 protein
Clonality
Polyclonal
Tag
VRK1
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
43kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of VRK1 protein
Observed Molecular Weight
43
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
Serine/threonine-protein kinase VRK1; Vaccinia-related kinase 1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q99986
Isotype
Rabbit IgG

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