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TRI56 Polyclonal Antibody

CAT: 0749-ABP60755-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP60755-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TRIM56 (Tripartite Motif Containing 56) is a Protein Coding gene. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System. GO annotations related to this gene include poly (A) RNA binding and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM3. E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed: 21289118) . In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to Lys-63-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity) . Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA) -induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed: 22948160) .
Description
Rabbit Anti-TRI56 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
E3 ubiquitin-protein ligase TRIM56; RING finger protein 109; RING-type E3 ubiquitin transferase TRIM56; Tripartite motif-containing protein 56
Gene ID
81844
Accession Number
Q9BRZ2
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human TRI56 protein at amino acid sequence of 121-170
Clonality
Polyclonal
Tag
TRI56
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
83kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of TRI56 protein
Observed Molecular Weight
83
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
E3 ubiquitin-protein ligase TRIM56; RING finger protein 109; RING-type E3 ubiquitin transferase TRIM56; Tripartite motif-containing protein 56
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q9BRZ2
Isotype
Rabbit IgG

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