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Ferruginol

CAT: 0804-HY-N6033-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6033-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ferruginol ((+) -Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA) . Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities[1][2][3].
CAS Number
514-62-5
Product Name Alternative
(+) -Ferruginol
UNSPSC
12352005
Target
Apoptosis; EBV; HSV
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ferruginol.html
Purity
96.91
Solubility
10 mM in DMSO
Smiles
[H][C@]1(CCC2=C3)C(C)(C)CCC[C@]1(C)C2=CC(O)=C3C(C)C
Molecular Formula
C20H30O
Molecular Weight
286.45
References & Citations
[1]Manabu Iwamoto, et al. Potential antitumor promoting diterpenoids from the stem bark of Thuja standishii. Planta Med. 2003 Jan;69 (1) :69-72.|[2]Guoqing Luo, et al. Ferruginol Diterpenoid Selectively Inhibits Human Thyroid Cancer Growth by Inducing Mitochondrial Dependent Apoptosis, Endogenous Reactive Oxygen Species (ROS) Production, Mitochondrial Membrane Potential Loss and Suppression of Mitogen-Activated Protein Kinase (MAPK) and PI3K/AKT Signaling Pathways. Med Sci Monit. 2019 Apr 21;25:2935-2942.|[3]Weili Li, et al. Ferruginol Restores SIRT1-PGC-1α-Mediated Mitochondrial Biogenesis and Fatty Acid Oxidation for the Treatment of DOX-Induced Cardiotoxicity. Front Pharmacol. 2021 Nov 24;12:773834.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
TN1642Ferruginol

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