PRP8 Polyclonal Antibody

• Background :

  Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by PRPF8 (Pre-MRNA Processing Factor 8) is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. PRPF8 is a candidate gene for autosomal dominant retinitis pigmentosa.

• Description :

  Rabbit Anti-PRP8 Polyclonal Antibody

• Product Name Alternative :

  Pre-mRNA-processing-splicing factor 8; 220 kDa U5 snRNP-specific protein; PRP8 homolog; Splicing factor Prp8; p220

• Gene ID :

  10594

• Accession Number :

  Q6P2Q9

• Reactivity :

  Human, Mouse

• Immunogen :

  Synthesized peptide derived from part region of human PRP8 protein at amino acid sequence of 160-240

• Clonality :

  Polyclonal

• Tag :

  PRP8

• Applications :

  IHC, IF

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  256kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  The antibody detects endogenous levels of PRP8 protein

• Observed Molecular Weight :

  256

• Formulation :

  Liquid solution

• Buffer pH :

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300; IF 1:50-200

• Other Product Names :

  Pre-mRNA-processing-splicing factor 8; 220 kDa U5 snRNP-specific protein; PRP8 homolog; Splicing factor Prp8; p220

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/Q6P2Q9

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG