Adenylyl cyclase type 2 agonist-1

• UNSPSC Description:

  Adenylyl cyclase type 2 agonist-1 (Compound 73) is a potent agonist of adenylyl cyclase type 2 (AC2) with the EC50 of 90 nM. Adenylyl cyclase type 2 agonist-1 inhibits expression of Interleukin-6, making it a potential lead compound against respiratory diseases[1].

• Target Antigen:

  Adenylate Cyclase

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/adenylyl-cyclase-type-2-agonist-1.html

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  [H][C@@]1(OC2([C@]3(C(N(C([C@@]13[H])=O)C4=CC=CC=C4Cl)=O)[H])C(C5=C(C2=O)C=CC(Br)=C5)=O)C6=CC=C(C=C6)C

• Molecular Weight:

  550.78

• References & Citations:

  [1]Guowei Xu, et al. The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation. Eur J Med Chem. 2020 Apr 1;191:112115.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2414908-52-2