MPP8 Polyclonal Antibody

CAT: 0749-ABP59318-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP59318-01Size:30 µL
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
MPHOSPH8 (M-Phase Phosphoprotein 8) is a Protein Coding gene. Heterochromatin component that specifically recognizes and binds methylated Lys-9 of histone H3 and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.
Description
Rabbit Anti-MPP8 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
M-phase phosphoprotein 8; Two hybrid-associated protein 3 with RanBPM; Twa3
Gene ID
54737
Accession Number
Q99549
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from part region of human MPP8 protein at amino acid sequence of 290-370
Clonality
Polyclonal
Tag
MPP8
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
94kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of MPP8 protein
Observed Molecular Weight
94
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
M-phase phosphoprotein 8; Two hybrid-associated protein 3 with RanBPM; Twa3
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q99549
Isotype
Rabbit IgG

Popular Products