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Magnolol

CAT: 0804-HY-N0163-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0163-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively.
CAS Number
528-43-8
UNSPSC
12352005
Hazard Statement
H315, H318, H335, H411
Target
Autophagy; Bacterial; PPAR; RAR/RXR
Type
Natural Products
Related Pathways
Anti-infection; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Magnolol.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=C(CC=C)C=C1C2=CC(CC=C)=CC=C2O
Molecular Formula
C18H18O2
Molecular Weight
266.33
Precautions
H315, H318, H335, H411
References & Citations
[1]Zhang H, et al. Molecular determinants of magnolol targeting both RXRα and PPARγ. PLoS One. 2011;6 (11) :e28253.|[2]Choi SS, et al. Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Life Sci. 2009 Jun 19;84 (25-26) :908-14.|[3]Zhao L, et al. Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules. 2017 Jul 20;22 (7) . pii: E1218.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
PPARγ

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