LRBA Polyclonal Antibody

• Background :

  LRBA (LPS Responsive Beige-Like Anchor Protein) is a Protein Coding gene. Diseases associated with LRBA include Immunodeficiency, Common Variable, 8, With Autoimmunity and Lrba-Related Common Variable Immune Deficiency. The protein encoded by LRBA is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS) . The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in LRBA are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for LRBA.

• Description :

  Rabbit Anti-LRBA Polyclonal Antibody

• Product Name Alternative :

  Lipopolysaccharide-responsive and beige-like anchor protein; Beige-like protein; CDC4-like protein

• Gene ID :

  987

• Accession Number :

  P50851

• Reactivity :

  Human, Mouse

• Immunogen :

  Synthesized peptide derived from part region of human LRBA protein at amino acid sequence of 1970-2050

• Clonality :

  Polyclonal

• Tag :

  LRBA

• Applications :

  IHC, IF

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  314kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  The antibody detects endogenous levels of LRBA protein

• Observed Molecular Weight :

  314

• Formulation :

  Liquid solution

• Buffer pH :

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300; IF 1:50-200

• Other Product Names :

  Lipopolysaccharide-responsive and beige-like anchor protein; Beige-like protein; CDC4-like protein

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/P50851

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG