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LRBA Polyclonal Antibody

CAT: 0749-ABP59140-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP59140-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
LRBA (LPS Responsive Beige-Like Anchor Protein) is a Protein Coding gene. Diseases associated with LRBA include Immunodeficiency, Common Variable, 8, With Autoimmunity and Lrba-Related Common Variable Immune Deficiency. The protein encoded by LRBA is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS) . The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in LRBA are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for LRBA.
Description
Rabbit Anti-LRBA Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Lipopolysaccharide-responsive and beige-like anchor protein; Beige-like protein; CDC4-like protein
Gene ID
987
Accession Number
P50851
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human LRBA protein at amino acid sequence of 1970-2050
Clonality
Polyclonal
Tag
LRBA
Applications
IHC, IF
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
314kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of LRBA protein
Observed Molecular Weight
314
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300; IF 1:50-200
Other Product Names
Lipopolysaccharide-responsive and beige-like anchor protein; Beige-like protein; CDC4-like protein
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P50851
Isotype
Rabbit IgG

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