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LGMN Polyclonal Antibody

CAT: 0749-ABP59112-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP59112-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
LGMN encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of LGMN may be associated with the majority of solid tumor types. LGMN has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.
Description
Rabbit Anti-LGMN Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Legumain; Asparaginyl endopeptidase; Protease; cysteine 1
Gene ID
5641
Accession Number
Q99538
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from part region of human LGMN protein at amino acid sequence of 60-140
Clonality
Polyclonal
Tag
LGMN
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
47kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of LGMN protein
Observed Molecular Weight
47
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
Legumain; Asparaginyl endopeptidase; Protease; cysteine 1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q99538
Isotype
Rabbit IgG

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