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Keratin 8 Polyclonal Antibody

CAT: 0749-ABP59033-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP59033-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
KRT8 (Keratin 8) is a Protein Coding gene. Diseases associated with KRT8 include Cirrhosis, Cryptogenic and Hidrocystoma. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Keratinization. KRT8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of KRT8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in KRT8 cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for KRT8.
Description
Rabbit Anti-Keratin 8 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Keratin, type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8
Gene ID
3856
Accession Number
P05787
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from part region of human Keratin 8 protein
Clonality
Polyclonal
Tag
Keratin 8
Applications
WB, ELISA, IHC
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
53kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
This antibody detects endogenous levels of Keratin 8.
Observed Molecular Weight
53
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Other Product Names
Keratin, type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P05787
Isotype
Rabbit IgG

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