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GPX3 Polyclonal Antibody

CAT: 0749-ABP58707-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP58707-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Glutathione Peroxidase 3 encoded by GPX3 belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.
Description
Rabbit Anti-GPX3 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Glutathione peroxidase 3; GPx-3; GSHPx-3; Extracellular glutathione peroxidase; Plasma glutathione peroxidase; GPx-P; GSHPx-P
Gene ID
2878
Accession Number
P22352
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from part region of human GPX3 protein
Clonality
Polyclonal
Tag
GPX3
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
24kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of GPX3 protein
Observed Molecular Weight
24
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
Glutathione peroxidase 3; GPx-3; GSHPx-3; Extracellular glutathione peroxidase; Plasma glutathione peroxidase; GPx-P; GSHPx-P
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P22352
Isotype
Rabbit IgG

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