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GDNF Polyclonal Antibody

CAT: 0749-ABP58627-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP58627-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GDNF encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in GDNF may be associated with Hirschsprung disease and Tourette syndrome. GDNF encodes multiple protein isoforms that may undergo similar proteolytic processing.
Description
Rabbit Anti-GDNF Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Glial cell line-derived neurotrophic factor; hGDNF; Astrocyte-derived trophic factor; ATF
Gene ID
2668
Accession Number
P39905
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from part region of human GDNF protein at amino acid sequence of 100-180
Clonality
Polyclonal
Tag
GDNF
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
23kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of GDNF protein
Observed Molecular Weight
23
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
Glial cell line-derived neurotrophic factor; hGDNF; Astrocyte-derived trophic factor; ATF
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P39905
Isotype
Rabbit IgG

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