DNA2 Polyclonal Antibody

• Background:

  DNA2 (DNA Replication Helicase/Nuclease 2) is a Protein Coding gene. Diseases associated with DNA2 include Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 6 and Seckel Syndrome 8. Among its related pathways are DNA Double-Strand Break Repair and Telomere C-strand (Lagging Strand) Synthesis. DNA2 encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in DNA2 are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for DNA2.

• Description:

  Rabbit Anti-DNA2 Polyclonal Antibody

• Product Name Alternative:

  DNA replication ATP-dependent helicase/nuclease DNA2; hDNA2; DNA replication ATP-dependent helicase-like homolog; DNA replication nuclease DNA2 ; DNA replication ATP-dependent helicase DNA2

• Gene ID:

  1763

• Accession Number:

  P51530

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthesized peptide derived from part region of human DNA2 protein

• Clonality:

  Polyclonal

• Tag:

  DNA2

• Applications:

  WB, ELISA

• Purification Method:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Molecular Weight:

  116kD

• Precautions:

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions:

  Gel pack with blue ice.

• Storage Conditions:

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes:

  The antibody detects endogenous levels of DNA2 protein

• Observed Molecular Weight:

  116

• Formulation:

  Liquid solution

• Buffer pH:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Applications Notes:

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000

• Other Product Names:

  DNA replication ATP-dependent helicase/nuclease DNA2; hDNA2; DNA replication ATP-dependent helicase-like homolog; DNA replication nuclease DNA2 ; DNA replication ATP-dependent helicase DNA2

• Tested Applications:

  WB, IHC, IF, IP, ELISA

• Host or Source:

  Rabbit

• Accession Number URL:

  http://www.uniprot.org/uniprot/P51530

• CAS Number:

  9007-83-4

• Isotype:

  Rabbit IgG