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DMP1 Polyclonal Antibody

CAT: 0749-ABP58392-01Size: 30 µLDry Ice: NoHazardous: No
CAT#: ABP58392-01Size: 30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. DMP1 structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for DMP1.
Description
Rabbit Anti-DMP1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Dentin matrix acidic phosphoprotein 1; DMP-1; Dentin matrix protein 1
Gene ID
1758
Accession Number
Q13316
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from part region of human DMP1 protein at amino acid sequence of 430-510
Clonality
Polyclonal
Tag
DMP1
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
56kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of DMP1 protein
Observed Molecular Weight
56
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
Dentin matrix acidic phosphoprotein 1; DMP-1; Dentin matrix protein 1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q13316
Isotype
Rabbit IgG

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