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DMA Polyclonal Antibody

CAT: 0749-ABP58389-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP58389-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. HLA-DMA (Major Histocompatibility Complex, Class II, DM Alpha) is a Protein Coding gene. Diseases associated with HLA-DMA include Rheumatoid Arthritis. Among its related pathways are Hematopoietic cell lineage and Allograft rejection.
Description
Rabbit Anti-DMA Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
HLA class II histocompatibility antigen, DM alpha chain; MHC class II antigen DMA; Really interesting new gene 6 protein
Gene ID
3108
Accession Number
P28067
Reactivity
Human
Immunogen
Synthesized peptide derived from part region of human DMA protein
Clonality
Polyclonal
Tag
DMA
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
28kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of DMA protein
Observed Molecular Weight
28
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
HLA class II histocompatibility antigen, DM alpha chain; MHC class II antigen DMA; Really interesting new gene 6 protein
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P28067
Isotype
Rabbit IgG

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