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CO5 Polyclonal Antibody

CAT: 0749-ABP58217-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP58217-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
C5 encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC) . Mutations in C5 cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants.
Description
Rabbit Anti-CO5 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
Gene ID
727
Accession Number
P01031
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from part region of human CO5 protein at amino acid sequence of 690-770
Clonality
Polyclonal
Tag
CO5
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
184kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of CO5 protein
Observed Molecular Weight
184
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:5000-20000
Other Product Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P01031
Isotype
Rabbit IgG

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