CAC1A Polyclonal Antibody

CAT: 0749-ABP57953-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP57953-01Size:30 µL
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Background
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. CACNA1A encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in CACNA1A are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. CACNA1A also exhibits polymorphic variation due to (CAG) n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG) n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG) n-repeats which encode a polyglutamine tract. Expansion of the (CAG) n-repeats from the normal 4-18 to 21-33 in the coding region is associated with spinocerebellar ataxia 6.
Description
Rabbit Anti-CAC1A Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Voltage-dependent P/Q-type calcium channel subunit alpha-1A; Brain calcium channel I; BI; Calcium channel, L type, alpha-1 polypeptide isoform 4; Voltage-gated calcium channel subunit alpha Cav2.1
Gene ID
773
Accession Number
O00555
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from part region of human CAC1A protein at amino acid sequence of 1401-1450
Clonality
Polyclonal
Tag
CAC1A
Applications
IHC, IF
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
275kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
The antibody detects endogenous levels of CAC1A protein
Observed Molecular Weight
275
Formulation
Liquid solution
Buffer pH
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300; IF 1:50-200
Other Product Names
Voltage-dependent P/Q-type calcium channel subunit alpha-1A; Brain calcium channel I; BI; Calcium channel, L type, alpha-1 polypeptide isoform 4; Voltage-gated calcium channel subunit alpha Cav2.1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O00555
Isotype
Rabbit IgG

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