ASPM Polyclonal Antibody

• Background :

  ASPM is the human ortholog of the Drosophila melanogaster ‘abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene. ASPM (Abnormal Spindle Microtubule Assembly) is a Protein Coding gene. Diseases associated with ASPM include Microcephaly 5, Primary, Autosomal Recessive and Primary Microcephaly.

• Description :

  Rabbit Anti-ASPM Polyclonal Antibody

• Product Name Alternative :

  Abnormal spindle-like microcephaly-associated protein; Abnormal spindle protein homolog; Asp homolog

• Gene ID :

  259266

• Accession Number :

  Q8IZT6

• Reactivity :

  Human, Mouse

• Immunogen :

  Synthesized peptide derived from part region of human ASPM protein at amino acid sequence of 1230-1310

• Clonality :

  Polyclonal

• Tag :

  ASPM

• Applications :

  IHC, IF

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  382kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  The antibody detects endogenous levels of ASPM protein

• Formulation :

  Liquid solution

• Buffer pH :

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300; IF 1:50-200

• Other Product Names :

  Abnormal spindle-like microcephaly-associated protein; Abnormal spindle protein homolog; Asp homolog

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/Q8IZT6

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG