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ARHGAP11A Polyclonal Antibody

CAT: 0749-ABP57102-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP57102-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. ARHGAP11A (Rho GTPase activating protein 11A), also known as KIAA0013 or MGC70740, is a 1,023 amino acid protein that contains one helical Rho-GAP domain and is encoded by a gene located on human chromosome 15. Defects in the gene encoding ARHGAP11A may cause mental retardation. Human chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene.
Description
Rabbit Anti-ARHGAP11A Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
ARHGAP11A; KIAA0013; Rho GTPase-activating protein 11A; Rho-type GTPase-activating protein 11A
Gene ID
9824
Accession Number
Q6P4F7
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human ARHGAP11A at AA range: 440-520
Clonality
Polyclonal
Tag
Rho GTPase-activating protein 11A
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
110kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
ARHGAP11A Polyclonal Antibody detects endogenous levels of ARHGAP11A protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Other Product Names
ARHGAP11A; KIAA0013; Rho GTPase-activating protein 11A; Rho-type GTPase-activating protein 11A
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q6P4F7
Isotype
Rabbit IgG

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