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CEP57 Polyclonal Antibody

CAT: 0749-ABP57088-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP57088-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CEP57 (centrosomal protein 57) encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in CEP57 cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Description
Rabbit Anti-CEP57 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CEP57; KIAA0092; TSP57; Centrosomal protein of 57 kDa; Cep57; FGF2-interacting protein; Testis-specific protein 57; Translokin
Gene ID
9702
Accession Number
Q86XR8
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human CEP57 at AA range: 210-290
Clonality
Polyclonal
Tag
Centrosomal protein of 57 kDa
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
50kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
CEP57 Polyclonal Antibody detects endogenous levels of CEP57 protein.
Observed Molecular Weight
50
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Other Product Names
CEP57; KIAA0092; TSP57; Centrosomal protein of 57 kDa; Cep57; FGF2-interacting protein; Testis-specific protein 57; Translokin
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q86XR8
Isotype
Rabbit IgG

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