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PRPF38A Polyclonal Antibody

CAT: 0749-ABP56791-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP56791-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PRPF38A (Pre-mRNA-splicing factor 38A) is a 312 amino acid nuclear protein that is likely required for pre-mRNA splicing. There are two isoforms of PRPF38A that are produced as a result of alternative splicing events. The gene encoding PRPF38A maps to human chromosome 1, the largest human chromosome which spans about 260 million base pairs and makes up 8% of the human genome. There are about 3000 genes on chromosome 1 and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.
Description
Rabbit Anti-PRPF38A Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
PRPF38A; Pre-mRNA-splicing factor 38A
Gene ID
84950
Accession Number
Q8NAV1
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human PRPF38A at AA range: 80-160
Clonality
Polyclonal
Tag
Pre-mRNA-splicing factor 38A
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
40kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
PRPF38A Polyclonal Antibody detects endogenous levels of PRPF38A protein.
Observed Molecular Weight
40
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Other Product Names
PRPF38A; Pre-mRNA-splicing factor 38A
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q8NAV1
Isotype
Rabbit IgG

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