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COL25A1 Polyclonal Antibody

CAT: 0749-ABP56763-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP56763-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
COL25A1 (collagen type XXV alpha 1 chain) encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410) . A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013) . Multiple transcript variants encoding different isoforms have been found for COL25A1.
Description
Rabbit Anti-COL25A1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
COL25A1; Collagen alpha-1 (XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P
Gene ID
84570
Accession Number
Q9BXS0
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human COL25A1 at AA range: 70-150
Clonality
Polyclonal
Tag
Collagen alpha-1 (XXV) chain
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
64kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
COL25A1 Polyclonal Antibody detects endogenous levels of COL25A1 protein.
Observed Molecular Weight
64
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Other Product Names
COL25A1; Collagen alpha-1 (XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q9BXS0
Isotype
Rabbit IgG

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