COL18A1 Polyclonal Antibody

CAT: 0749-ABP56623-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP56623-01Size:30 µL
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Background
COL18A1 (collagen type XVIII alpha 1 chain) encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in COL18A1 are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.
Description
Rabbit Anti-COL18A1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
COL18A1; Collagen alpha-1 (XVIII) chain
Gene ID
80781
Accession Number
P39060
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the C-terminal region of human COL18A1 at AA range: 1270-1350
Clonality
Polyclonal
Tag
Collagen alpha-1 (XVIII) chain
Applications
IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
COL18A1 Polyclonal Antibody detects endogenous levels of COL18A1 protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Other Product Names
COL18A1; Collagen alpha-1 (XVIII) chain
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P39060
Isotype
Rabbit IgG

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