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Tsg 101 Polyclonal Antibody

CAT: 0749-ABP56454-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP56454-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by TSG101 (tumor susceptibility 101) belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in TSG101 occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
Description
Rabbit Anti-Tsg 101 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
TSG101; Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101
Gene ID
7251
Accession Number
Q99816
Reactivity
Human, Mouse, Rat, Monkey
Immunogen
Synthesized peptide derived from the C-terminal region of human Tsg 101 at AA range: 250-330
Clonality
Polyclonal
Tag
Tumor susceptibility gene 101 protein
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
45kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Tsg 101 Polyclonal Antibody detects endogenous levels of Tsg 101 protein.
Observed Molecular Weight
44
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications.
Other Product Names
TSG101; Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q99816
Isotype
Rabbit IgG

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