TFE3 Polyclonal Antibody

• Background:

  TFE3 (transcription factor binding to IGHM enhancer 3) encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. TFE3 may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants.

• Description:

  Rabbit Anti-TFE3 Polyclonal Antibody

• Product Name Alternative:

  TFE3; BHLHE33; Transcription factor E3; Class E basic helix-loop-helix protein 33; bHLHe33

• Gene ID:

  7030

• Accession Number:

  P19532

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthesized peptide derived from the Internal region of human TFE3 at AA range: 70-150

• Clonality:

  Polyclonal

• Tag:

  Transcription factor E3

• Applications:

  WB, IHC, IF, ELISA

• Purification Method:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Molecular Weight:

  62kD

• Precautions:

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions:

  Gel pack with blue ice.

• Storage Conditions:

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes:

  TFE3 Polyclonal Antibody detects endogenous levels of TFE3 protein.

• Observed Molecular Weight:

  62

• Formulation:

  Liquid solution

• Buffer pH:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes:

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200

• Other Product Names:

  TFE3; BHLHE33; Transcription factor E3; Class E basic helix-loop-helix protein 33; bHLHe33

• Tested Applications:

  WB, IHC, IF, IP, ELISA

• Host or Source:

  Rabbit

• Accession Number URL:

  http://www.uniprot.org/uniprot/P19532

• CAS Number:

  9007-83-4

• Isotype:

  Rabbit IgG