Stat6 Polyclonal Antibody

CAT: 0749-ABP56304-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP56304-01Size:30 µL
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Background
The protein encoded by STAT6 (signal transducer and activator of transcription 6) is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
Description
Rabbit Anti-Stat6 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
STAT6; Signal transducer and activator of transcription 6; IL-4 Stat
Gene ID
6778
Accession Number
P42226
Reactivity
Human, Mouse, Monkey
Immunogen
Synthesized peptide derived from human Stat6 around the non-phosphorylation site of Y641
Clonality
Polyclonal
Tag
Signal transducer and activator of transcription 6
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
94kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Stat6 Polyclonal Antibody detects endogenous levels of Stat6 protein.
Observed Molecular Weight
94
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Other Product Names
STAT6; Signal transducer and activator of transcription 6; IL-4 Stat
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P42226
Isotype
Rabbit IgG

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