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Shb Polyclonal Antibody

CAT: 0749-ABP56188-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP56188-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The SH2 (Src Homology 2) domain is a structurally conserved motif that contains two alpha helices and seven beta strands and is found in a variety of proteins that are involved in signal transduction throughout the cell. Specifically, the SH2 domain targets SH2 domain-containing proteins to tyrosine-phosphorylated sites, an event that can trigger a protein-protein interaction cascade which may ultimately effect gene expression and cellular function. Shb (SH2 domain-containing adapter protein b), Shd (SH2 domain-containing adapter protein d), She (SH2 domain-containing adapter protein e) and Shf (SH2 domain-containing adapter protein f) are SH2 domain-containing proteins that play various roles throughout the cell. Shb is a widely expressed protein that localizes to both the cell membrane and the cytoplasm and plays an important role in signal transduction, mainly by linking activated proteins to downstream signaling targets, thereby propagating a signal cascade. Unlike Shb, Shd and Shf are thought to function as adaptor proteins, the former of which may be involved in apoptotic regulation.
Description
Rabbit Anti-Shb Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
SHB; SH2 domain-containing adapter protein B
Gene ID
6461
Accession Number
Q15464
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the C-terminal region of human Shb at AA range: 380-460
Clonality
Polyclonal
Tag
SH2 domain-containing adapter protein B
Applications
WB, ELISA, IHC
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
55kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Shb Polyclonal Antibody detects endogenous levels of Shb protein.
Observed Molecular Weight
55
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Other Product Names
SHB; SH2 domain-containing adapter protein B
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q15464
Isotype
Rabbit IgG

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