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PHKB Polyclonal Antibody

CAT: 0749-ABP55586-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP55586-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by PHKB (phosphorylase kinase regulatory subunit beta), which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in PHKB cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.
Description
Rabbit Anti-PHKB Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
PHKB; Phosphorylase b kinase regulatory subunit beta; Phosphorylase kinase subunit beta
Gene ID
5257
Accession Number
Q93100
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human PHKB at AA range: 630-710
Clonality
Polyclonal
Tag
Phosphorylase b kinase regulatory subunit beta
Applications
WB, IHC
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
124kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
PHKB Polyclonal Antibody detects endogenous levels of PHKB protein.
Observed Molecular Weight
124
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300
Other Product Names
PHKB; Phosphorylase b kinase regulatory subunit beta; Phosphorylase kinase subunit beta
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q93100
Isotype
Rabbit IgG

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