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Atm Polyclonal Antibody

CAT: 0749-ABP55350-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP55350-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Description
Rabbit Anti-Atm Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Gene ID
472
Accession Number
Q13315
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from human Atm around the non-phosphorylation site of S1981
Clonality
Polyclonal
Tag
Serine-protein kinase ATM
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Atm Polyclonal Antibody detects endogenous levels of Atm protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300; ELISA 1:10000; WB 1:500-2000; IF 1:50-200
Other Product Names
ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q13315
Isotype
Rabbit IgG

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