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NACA (phospho Ser43) Polyclonal Antibody

CAT: 0749-ABP55329-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP55329-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NACA encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC) . This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of NACA on different chromosomes.
Description
Rabbit Anti-NACA (phospho Ser43) Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
NACA; HSD48; Nascent polypeptide-associated complex subunit alpha; NAC-alpha; Alpha-NAC; allergen Hom s 2
Gene ID
4666
Accession Number
Q13765
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human NACA around the phosphorylation site of S43
Clonality
Polyclonal
Tag
Nascent polypeptide-associated complex subunit alpha
Applications
IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Phospho-NACA (S43) Polyclonal Antibody detects endogenous levels of NACA protein only when phosphorylated at S43.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Other Product Names
NACA; HSD48; Nascent polypeptide-associated complex subunit alpha; NAC-alpha; Alpha-NAC; allergen Hom s 2
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q13765
Isotype
Rabbit IgG

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