HUNK Polyclonal Antibody

CAT: 0749-ABP54732-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP54732-01Size:30 µL
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Background
The HUNK (hormonally upregulated Neu-associated kinase) protein, also designated MAK-V in mouse, has been identified as a novel SNF1-related serine/threonine kinase. The human HUNK gene localizes to chromosome 21q22 and encodes a protein with nucleocytoplasmic distribution and localizes to the centrosome. Overexpression of the HUNK protein associates with approximately 50% of breast carcinomas, and may provide diagnostic-prognostic value as a molecular marker. Serine/threonine-protein kinase SNF1-like kinase 2 (SIK) phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, which may modulate the efficiency of insulin signal transduction. SIK is activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-alpha and CAB39.
Description
Rabbit Anti-HUNK Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
HUNK; MAKV; Hormonally up-regulated neu tumor-associated kinase; B19; Serine/threonine-protein kinase MAK-V
Gene ID
30811
Accession Number
P57058
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human HUNK at AA rangle: 220-300
Clonality
Polyclonal
Tag
Hormonally up-regulated neu tumor-associated kinase
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
75kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
HUNK Polyclonal Antibody detects endogenous levels of HUNK protein.
Observed Molecular Weight
75
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Other Product Names
HUNK; MAKV; Hormonally up-regulated neu tumor-associated kinase; B19; Serine/threonine-protein kinase MAK-V
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P57058
Isotype
Rabbit IgG

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