AX-024 (hydrochloride)
CAT:
804-HY-107390A-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
AX-024 (hydrochloride)
- CAS Number: 1704801-24-0
- UNSPSC Description: AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
- Target Antigen: IFNAR; Interleukin Related; TNF Receptor
- Type: Reference compound
- Related Pathways: Apoptosis;Immunology/Inflammation
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology; Cancer
- Assay Protocol: https://www.medchemexpress.com/ax-024-hydrochloride.html
- Purity: 99.75
- Solubility: DMSO : 33 mg/mL (ultrasonic;warming)|H2O : 16.67 mg/mL (ultrasonic)
- Smiles: COC1=CC=C(OC2)C(C(C3=CC=C(F)C=C3)=C2CN4CCCC4)=C1.[H]Cl
- Molecular Weight: 375.86
- References & Citations: [1]Borroto A, et al. First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci Transl Med. 2016 Dec 21;8(370):370ra184.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Phase 1