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5-LO Polyclonal Antibody

CAT: 0749-ABP54393-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP54393-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ALOX5 encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The arachidonate 5-lipoxygenasen, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5 (S) -hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5 (S) -trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4) . Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Description
Rabbit Anti-5-LO Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
ALOX5; LOG5; Arachidonate 5-lipoxygenase; 5-LO; 5-lipoxygenase
Gene ID
240
Accession Number
P09917
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human 5-LO around the non-phosphorylation site of S272
Clonality
Polyclonal
Tag
Arachidonate 5-lipoxygenase
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
78kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
5-LO Polyclonal Antibody detects endogenous levels of 5-LO protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Other Product Names
ALOX5; LOG5; Arachidonate 5-lipoxygenase; 5-LO; 5-lipoxygenase
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P09917
Isotype
Rabbit IgG

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