Azido-PEG5-alcohol
CAT:
804-HY-130211-03
Size:
250 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Azido-PEG5-alcohol
- CAS Number: 86770-68-5
- UNSPSC Description: Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG5-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Target Antigen: ADC Linker; PROTAC Linkers
- Type: ADC Related
- Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/azido-peg5-alcohol.html
- Purity: 97.0
- Solubility: 10 mM in DMSO
- Smiles: OCCOCCOCCOCCOCCN=[N+]=[N-]
- Molecular Weight: 263.29
- References & Citations: [1]Zhang FL, et al. Molecular-target-based anticancer photosensitizer: synthesis and in vitro photodynamic activity of erlotinib-zinc(II) phthalocyanine conjugates. ChemMedChem. 2015 Feb;10(2):312-20.|[2] Nan JI, et al. Mertk degraders and uses thereof. WO2020010210A1.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported