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Cerebral 1 Polyclonal Antibody

CAT: 0749-ABP54336-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP54336-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RRP8 (Ribosomal RNA Processing 8, Methyltransferase, Homolog (Yeast) is a Protein Coding gene. Diseases associated with RRP8 include bowen-conradi syndrome and lymphatic system cancer. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include poly (A) RNA binding and methylated histone binding. ssential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD (+) /NADP (+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at Lys-9 (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Description
Rabbit Anti-Cerebral 1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
RRP8; KIAA0409; NML; hucep-1; Ribosomal RNA-processing protein 8; Cerebral protein 1; Nucleomethylin
Gene ID
23378
Accession Number
O43159
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human Cerebral 1 at AA rangle: 240-320
Clonality
Polyclonal
Tag
Ribosomal RNA-processing protein 8
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
51kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Cerebral 1 Polyclonal Antibody detects endogenous levels of Cerebral 1 protein.
Observed Molecular Weight
51
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Other Product Names
RRP8; KIAA0409; NML; hucep-1; Ribosomal RNA-processing protein 8; Cerebral protein 1; Nucleomethylin
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O43159
Isotype
Rabbit IgG

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