Smad1 Polyclonal Antibody

CAT: 0749-ABP53078-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP53078-01Size:30 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
SMAD family member 1 encoded by SMAD1 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ‘mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Description
Rabbit Anti-Smad1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
SMAD1; BSP1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; JV4-1; Mad-related protein 1; SMAD family member 1; SMAD 1; Smad1; hSMAD1; Transforming growth factor-beta-signaling protein 1; BSP-1
Gene ID
4086
Accession Number
Q15797
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human Smad1 around the non-phosphorylation site of S214
Clonality
Polyclonal
Tag
Mothers against decapentaplegic homolog 1
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
52kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Smad1 Polyclonal Antibody detects endogenous levels of Smad1 protein only when non-phosphorylation at S214.
Observed Molecular Weight
52
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000; IF 1:50-200
Other Product Names
SMAD1; BSP1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; JV4-1; Mad-related protein 1; SMAD family member 1; SMAD 1; Smad1; hSMAD1; Transforming growth factor-beta-signaling protein 1; BSP-1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q15797
Isotype
Rabbit IgG

Related Products

CatalogName
ABP52457-01Smad1/5/9 Polyclonal Antibody
ABP60436-01Smad1/5/9 Polyclonal Antibody
ABP50458-01Smad1 (phospho Ser465) Polyclonal Antibody
ABP55153-01Smad1 (phospho Ser187) Polyclonal Antibody
PPT-15349Human SMAD1 Recombinant Protein
ABP52463-01Smad3 Polyclonal Antibody
ANT-14454-50ugSMAD3 Polyclonal Antibody
ABP0159Smad4 Polyclonal Antibody
ABP57271-01Smad2 Polyclonal Antibody
ABP52818-01Smad5 Polyclonal Antibody

Alternative Products

CatalogName
JOT-AP08375-01Smad1 Polyclonal Antibody

Popular Products