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IL-10 Polyclonal Antibody

CAT: 0749-ABP52869-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP52869-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interleukin-10 encoded by IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Description
Rabbit Anti-IL-10 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
IL10; Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF
Gene ID
3586
Accession Number
P22301
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human IL-10
Clonality
Polyclonal
Tag
Interleukin-10
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
20kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
IL-10 Polyclonal Antibody detects endogenous levels of IL-10 protein.
Observed Molecular Weight
20
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:100-300; Not yet tested in other applications.
Other Product Names
IL10; Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P22301
Isotype
Rabbit IgG

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