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USP50 Polyclonal Antibody

CAT: 0749-ABP52682-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP52682-01Size:30 µL
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Background
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP50 (ubiquitin specific peptidase 50) is a 339 amino acid protein that belongs to the peptidase C19 family of proteins. Weakly expressed in a few tissues, USP50 contains all of the active residues necessary to function as a deubiquitinating enzyme, but it appears to be catalytically inactive. The gene ecoding USP50 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
Description
Rabbit Anti-USP50 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
USP50; Inactive ubiquitin carboxyl-terminal hydrolase 50; Inactive ubiquitin-specific peptidase 50
Gene ID
373509
Accession Number
Q70EL3
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the C-terminal region of human USP50 at AA range: 220-300
Clonality
Polyclonal
Tag
Inactive ubiquitin carboxyl-terminal hydrolase 50
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
38kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
USP50 Polyclonal Antibody detects endogenous levels of USP50 protein.
Observed Molecular Weight
38
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Other Product Names
USP50; Inactive ubiquitin carboxyl-terminal hydrolase 50; Inactive ubiquitin-specific peptidase 50
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q70EL3
Isotype
Rabbit IgG

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